{"id":2634,"date":"2015-06-10T11:24:00","date_gmt":"2015-06-10T09:24:00","guid":{"rendered":"https:\/\/forschungsnetzwerk-chim.de\/?post_type=publikationen&#038;p=2634"},"modified":"2024-01-26T13:29:30","modified_gmt":"2024-01-26T12:29:30","slug":"a-two-level-approach-for-fusing-early-signaling-events-and-long-term-cellular-responses","status":"publish","type":"publikationen","link":"https:\/\/forschungsnetzwerk-chim.de\/en\/publications\/a-two-level-approach-for-fusing-early-signaling-events-and-long-term-cellular-responses\/","title":{"rendered":"A Two-level Approach for Fusing Early Signaling Events and Long Term Cellular Responses"},"content":{"rendered":"\n<p>In biological systems, reactions on different time scales exist and need to be considered for the analysis of physiological reactions such as proliferation. In this contribution we describe a two-level approach to decode biological reactions on a short time-scale, e. g. signaling, into long term cellular responses, e. g. proliferation. First, we derive a valid and parametrized dynamic model for signaling events on the short time-scale using set-based estimation methods allowing to take uncertainties into account. Second, the derived model candidate for early signaling events is fused with a model for long term proliferation using shape-based signaling properties. This approach is realized in the specific case study of Interleukin-6-induced signaling and proliferation. Our modeling approach enables us to consider both, dynamic early signaling events and static long term events. Furthermore, it allows a deeper understanding of how cells process information from early signaling events to long term cellular responses.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><b>Publication:<\/b> 2015<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"beteiligte":[],"class_list":["post-2634","publikationen","type-publikationen","status-publish","hentry","publikationen_category-organic-chemistry"],"acf":[],"_links":{"self":[{"href":"https:\/\/forschungsnetzwerk-chim.de\/en\/wp-json\/wp\/v2\/publikationen\/2634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forschungsnetzwerk-chim.de\/en\/wp-json\/wp\/v2\/publikationen"}],"about":[{"href":"https:\/\/forschungsnetzwerk-chim.de\/en\/wp-json\/wp\/v2\/types\/publikationen"}],"wp:attachment":[{"href":"https:\/\/forschungsnetzwerk-chim.de\/en\/wp-json\/wp\/v2\/media?parent=2634"}],"wp:term":[{"taxonomy":"beteiligte","embeddable":true,"href":"https:\/\/forschungsnetzwerk-chim.de\/en\/wp-json\/wp\/v2\/beteiligte?post=2634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}